用于毛细管电泳手性分离的一种新的手性选择剂－ Β环糊精聚合物

用新合成的Β 环糊精聚合物(EP-Β-CD),并以天然环糊精(Β-CD) 和羧甲基环糊精(CM-Β-CD)手性拆分剂作对比,选取扑尔敏、山梗菜碱、维拉帕米为测试物􀁯优化分离条件􀁯研究了EP-Β-CD的拆分能力􀁯并与其它两种拆分剂进行了比较。

A novel chiral selector in capillary electrophoresis--beta-cyclodextrin polymer]

Three chiral selectors CM-beta-CD, EP-beta-CD, beta-CD were studied for the enatio-separation of three drugs under optimum conditions respectively. The results demonstrate that the resolving power for the drugs is as follows CM-beta-CD > EP-beta-CD > beta-CD, with the exception of lobeline. This is due to the--CH2COOCH3 group of CM-beta-CD, which will change the combination and improve the recognition on guest molecules. Although EP-beta-CD is inferior to CM-beta-CD for the separation of chlorpheniramine and verapamil, it has excellent recognition on lobeline and it has not been reported previously. In most cases EP-beta-CD is superior to beta-CD. The explanations are: (1) EP-beta-CD has good solubility in water, which enables high concentrations to be used and consequently achieves excellant separation of racemic compounds, (2) the polymerization of beta-CD changes the properties of CD units and the process produces a more rigid and different conformation from CD, (3) we must attribute much merits to the cooperation or synergism of two, three or even more CD moieties of two polymers for inclusion. Complexation with analytes possesses more than one guest part in their structure.