Enantioselective chromatography: Selection of chiral recognition models |
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Authors: | Wolfgang Lindner |
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Affiliation: | (1) Institute of Pharmaceutical Chemistry, University of Graz, A-8010 Graz, Austria |
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Abstract: | In this brief overview diverse chiral recognition models and chiral host-guest (selector-selectand, SO-SA) relationships which are used in enantioselective chromatography are discussed. In particular it is focussed on aspects of chiral interactions on (a) small molecular brush type chiral stationary phases (CSPs) and on (b) biopolymer and synthetic polymer type CSPs. The importance and the great variability of intermolecular SO-SA bindings via complementary contact sites, also in connection with molecule conformations, is stressed. Some representative and selected examples of chromatographic enantioseparations are presented. |
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Keywords: | enantioseparation liquid chromatography chiral recognition |
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