A General Method for Synthesis of GPI Anchors Illustrated by the Total Synthesis of the Low-Molecular-Weight Antigen from Toxoplasma gondii |
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| Authors: | Tsai Yu-Hsuan Götze Sebastian Azzouz Nahid Hahm Heung Sik Seeberger Peter H Varon Silva Daniel |
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| Institution: | Department of Biomolecular Systems, Max Planck Institut of Colloids and Interfaces, Am Mühlenberg 1, 14424 Potsdam (Germany) http://www.mpikg.mpg.de/Biomolekulare_Systeme; Institute of Chemistry and Biochemistry, Free University of Berlin, Arnimallee 22, 14195 Berlin (Germany). |
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| Abstract: | Building blocks: A new, general synthetic strategy, which allows the construction of branched glycosylphosphatidylinositols (GPIs), enables the synthesis of parasitic glycolipid 1 from Toxoplasma gondii. In addition, the structure is further confirmed by recognition of monoclonal antibodies. |
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| Keywords: | cell surface antigens glycosylphosphatidylinositol natural products synthetic strategy Toxoplasma gondii |
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