Utilization of deuterium labelling and 13C NMR spectroscopy in the investigation of the condensation of 1-Methyl-5-nitroimidazole-2-aldehyde and 2-Amino-4-methylpyrimidine

The product obtained condensing l-methyl-5-nitroimidazole-2-aldehyde with 2-amino-4-trideuteriomethyl-pyrimidine and showing total deuterium incorporation at one of the olefinic carbons and partial deuterium incorporation para to the amino group, served to assign ¹³C and ¹H resonances in the condensation products 3. The nature of the species undergoing condensation has been inferred from labelling experiments and from ¹H and ¹³C nmr spectra of precursors and products in dimethylsulfoxide and trifluoroacetic acid.