4-hydroxy-2-quinolones. 95. Synthesis, structure, and antitubercular properties of hetarylamides of 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid |
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| Authors: | I. V. Ukrainets E. V. Kolesnik L. V. Sidorenko O. V. Gorokhova A. V. Turov |
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| Affiliation: | (1) National Pharmaceutical University, Kharkov, 61002, Ukraine;(2) Kiev Taras Shevchenko National University, Kiev, 01033, Ukraine |
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| Abstract: | The optimal conditions for obtaining hetarylamides of 4-hydroxy-2-oxo-1,2,5,6,7,8-hexahydroquinoline-3-carboxylic acid are suggested on the basis of derivatographic investigations. The 1H NMR spectra of the synthesized compounds, their spatial structure, and also the results of a study of their antitubercular properties are discussed. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 6, pp. 874–886, June, 2006. |
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| Keywords: | amides 4-hydroxy-2-oxoquinoline-3-carboxylic acids antitubercular activity X-ray structural analysis thermolysis |
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