Low-valent niobium-catalyzed reduction of alpha,alpha,alpha-trifluorotoluenes |
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| Authors: | Fuchibe Kohei Ohshima Yoshitaka Mitomi Ken Akiyama Takahiko |
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| Institution: | Department of Chemistry, Faculty of Science, Gakushuin University, 1-5-1 Mejiro Toshima-ku, Tokyo 171-8588, Japan. |
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| Abstract: | reaction: see text] In the presence of 5 mol % of niobium(V) chloride, alpha,alpha,alpha-trifluorotoluene derivatives were reduced with lithium aluminum hydride to give toluene derivatives in good yields. Stepwise, partial reduction of bis(trifluoromethyl)benzene derivative was also demonstrated. |
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