Separation and characterisation of products of the reaction between propionamide and formaldehyde |
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| Authors: | F C Normand D M Goodall S B Duckett M F H van-Tol |
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| Institution: | (1) Department of Chemistry, University of York, YO10 5DD Heslington, York, UK;(2) DSM Research, P.O. Box 18, 6160 MD Geleen, The Netherlands;(3) Present address: Pfizer Global Research & Development, Analytical R & D, CT13 9NJ Sandwich, Kent, UK |
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| Abstract: | Summary Propionamide-formaldehyde reaction products have been characterised using micellar electrokinetic chromatography (MEKC), HPLC-electrospray-MS
(HPLC-ES-MS) and time-of-flight-MS (TOF-MS). HPLC-MS-MS was used to distinguish between isomeric species. The MEKC separation
of all reaction products was obtained with good resolution and efficiency. Comparison of water-micelle distribution constants
(P
MEKC) for propionamide-formaldehyde with those for caprolactam-formaldehyde reaction products suggests that the concentration
of sodium dodecyl sulfate appropriate for use in MEKC is inversely related toP
MEKC. Quantification of all species containing one or two amide units was achieved using standard calibration, mass balance and
the assumption of identical absorption coefficients for the same functional groups in monomers and dimers. |
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| Keywords: | Column liquid chromatography Micellar electrokinetic chromatography Mass spectrometric detection Condensation products Propionamide and formaldehyde |
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