| Abstract: | The tert-butyl esters of 3-azidomethyl-, 3-isocyanatomethyl-, 3-chloromethyl-, and 3-p-nitrophenylvinyl-7α-chloro-1,1-dioxoceph-3-em-4-carboxylic acid, and also esters of 7α-chloro-3-methyl-1,1-dioxoceph-3-em-4-carboxylic acid, and of 7α-chloro-3-methyl-2-dimethylaminomethylene-1,1-dioxoceph-3-em-4-carboxylic acid have been synthesized. Results of cytotoxic screening of these compounds in relation to cancer and normal cells in vitro are correlated and analyzed. __________ Translated from Khimiya Geterotsiklicheskikh Soedinenii, No. 2, pp. 259–273, February, 2007. |
