高效毛细管电泳法手性拆分奥昔布宁对映体

以羟丙基-β-环糊精（HP-β-CD）作为手性选择剂，采用毛细管区带电泳模式，对盐酸奥昔布宁对映体进行手性分离，比较了β-CD和 HP-β-CD之间对药品的分离能力，考察了手性选择剂的浓度、背景电解质的pH 值、柱温、分离电压和三羟甲基氨基甲烷（Tris）在背景电解质磷酸盐中的用量等因素对盐酸奥昔布宁对映体分离的影响，在优化条件下，使盐酸奥昔布宁对映体达到基线分离。结果表明该方法重现性好、简便、快捷、实用性强、具有良好的应用前景。

Chiral Separation of Oxybutynin Enantiomers by High-Performance Capillary Zone Electrophoresis

Oxybutynin chloride enantiomers was separated with using the hydroxypropyl -β-cyclode -xtrin（HP-β-CD）as chiral selector by capillary zone electrophoresis (CZE), and the difference of enantioseparation ability between HP-β-CD and β-CD was compared. The best experimental conditions that hydrochloric oxybutynin enantiomers were separated by baseline were obtained by optimizing the main experimental conditions: such as water-soluble hydroxypropyl-β-cyclo -dextrin concentration, background buffer pH, capillary temperature, voltage and the amount of three hydroxymethyl-methane in phosphate background buffer, and so on. The method was reproducible, simple, quick, practical, and has good prospects.