EFFECT OF SINGLET OXYGEN QUENCHERS ON OXIDATIVE DAMAGE TO LIPOSOMES INITIATED BY PHOTOSENSITIZATION OR BY RADIOFREQUENCY DISCHARGE |
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| Authors: | S M Anderson N I Krinsky M J Stone D C Clagett |
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| Institution: | Department of Biochemistry and Pharmacology, Tufts University School of Medicine, Boston, Massachusetts 02111, U.S.A.;Departments of Chemistry and Medicinal Chemistry, Northeastern University, Boston, Massachusetts 02115, U.S.A.;Dewey and Almy Chemical Division, W. R. Grace and Co., Cambridge, Massachusetts 02140, U.S.A. |
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| Abstract: | Abstract —Lipid model membrane systems, liposomes, may be oxidized by both toluidine blue Osensitized photo-oxidation and radiofrequency-discharge-generated singiet oxygen. Oxidation can be followed by the appearance of lipid peroxides, malondialdehyde formation, and ultimately by the lysis of the liposomes. Inhibition of oxidation is observed in both systems using either β-carotene or DABCO. These observations are consistent with the view that type II (singlet oxygen) reactions are involved in this photodynamic system. |
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