|
|||||
|
|
| 稀土在鼠肝中的物种分布 | |
| 引用本文： | 卢然,朱严楣,陈杭亭,赵大庆,倪嘉缵,陈东,聂毓秀. 稀土在鼠肝中的物种分布[J]. 高等学校化学学报, 2002, 23(1): 1-5 |
| 作者姓名： | 卢然 朱严楣 陈杭亭 赵大庆 倪嘉缵 陈东 聂毓秀 |
| 作者单位： | 1. 中国科学院长春应用化学研究所稀土化学物理开放实验室 2. 国家电分析和光谱研究测试中心，长春，130022 3. 林大学基础医学院组织学与胚胎学教研室,长春,130021 |
| 基金项目： | 国家自然科学基金重大项目 (批准号 :2 9890 2 80 )，国家博士后科学基金资助 |
| 摘 要： | 采用 ICP-MS、微量蛋白层析分离技术 ,研究了长时间、低剂量混合稀土及短时间、高剂量硝酸镧分别对大鼠及小鼠作用后 ,稀土在鼠肝中的代谢累积及其物种分布 .结果表明 ,鼠肝中各稀土含量随给药剂量的增加而增大 ,其累积速度大小顺序为 La>Ce>Nd>Pr;经柱层析分离未得到与稀土特异结合的鼠肝蛋白 ;稀土可与多种鼠肝蛋白 (包括多种重要的酶 )结合 ,在一定条件下 ,稀土与其结合蛋白可发生解离 |
| 关 键 词： | 稀土 肝脏 物种分布 ICP－MS 生物效应 代谢累积 结合蛋白 微量蛋白层析分离技术 毒理 |
| 文章编号： | 0251-0790(2002)01-0001-05 |
| 修稿时间： | 2001-02-23 |
Species of Rare Earth in Rat Liver |
|
| LU Ran ,ZHU Yan Mei ,CHEN Hang Ting ,ZHAO Da Qing ,NI Jia Zuan. Species of Rare Earth in Rat Liver[J]. Chemical Research In Chinese Universities, 2002, 23(1): 1-5 | |
| Authors: | LU Ran ZHU Yan Mei CHEN Hang Ting ZHAO Da Qing NI Jia Zuan |
| Affiliation: | LU Ran 1,ZHU Yan Mei 1,CHEN Hang Ting 2,ZHAO Da Qing 1*,NI Jia Zuan 1 |
| Abstract: | The metabolic accumulation and species of rare earth in rat liver were investigated by ICP MS and chromatography after the rats were fed by a low dose of mixed rare earth for a long time or the administration of a high dose of lanthanum for a short time. It was found that the content of rare earth in the liver increased with the arising of dose of drug delivery. Their accumulation rate was different, for example, La>Ce>Nd>Pr. The protein which could combine with rare earth specially were not gotten through chromatography. It was suggested that rare earth could bind to many proteins voluntarily, such as some important enzymes and it might be separated from the combined proteins under certain conditions. |
| Keywords: | Rare Earth Liver Species distribution ICP MS |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |