Polarographic analysis of some cephalosporin antibiotics

Summary The cephalosporin derivatives moxalactam, cefazolin, cefuroxime, ceftriaxone and cefotaxime were studied by direct current, sampled direct current, differential pulse polarography and cyclic voltammetry. While moxalactam and cefazolin give rise to one reduction wave, cefuroxime, ceftriaxone and cefotaxime exhibit two reduction waves. The characteristics of corresponding electrode reactions and their analytical parameters are presented and discussed. Optimum pH-ranges for the determination of the five cephalosporins are given. Linear concentration ranges varied from 0.1 to 200 g/ml and limits of determination were of the order of 0.01 to 0.04 g/ml depending on the compound of interest. The precision of the proposed method is excellent with relative standard deviation around 1.3% at a concentration of 0.5 g/ml for all investigated cephalosporins.

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Polarographische Analyse einiger Cephalosporin-Antibiotica