Synthesis of Alkyl-Aryl Ethers by Copper-catalyzed Etherization Reactions of Aryl Fluorides with Tetraalkylammonium Bromides and H2O |
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| Authors: | Feng Wang Boxiao Tang Yexiang Xie Prof Dr Jinheng Li |
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| Institution: | Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education), Hunan Normal University, Changsha, Hunan 410081, China |
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| Abstract: | Synthesis of alkyl aryl ethers via copper‐catalyzed etherizations of electron‐deficient aryl fluorides with quaternary ammonium bromides and water has been developed. In the presence of Cu(OAc)2, POPh3 ( L4 ) and Cs2CO3, a variety of electron‐deficient aryl fluorides underwent the reaction with quaternary ammonium bromides and H2O in moderate to good yields. The mechanism was also discussed. |
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| Keywords: | copper POPh3 aryl fluoride quaternary ammonium bromide alkyl aryl ether etherization |
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