| 3,13-二羟基-1,5,8,11,15,18-六氮杂环二十烷的合成研究 |
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| 引用本文： | 梁峰,吴成泰. 3,13-二羟基-1,5,8,11,15,18-六氮杂环二十烷的合成研究[J]. 有机化学, 2004, 24(4): 423-425 |
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| 作者姓名： | 梁峰 吴成泰 |
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| 作者单位： | 武汉大学化学系,武汉,430072 |
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| 基金项目： | 国家自然科学基金 (No.2 9972 0 34)资助项目 . |
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| 摘 要： | 尝试了三种制备 3 ,13 二羟基 1,5 ,8,11,15 ,18 六氮杂环二十烷 ( 5 )的方法 .实验结果表明 1,3 二氯 2 丙醇 ( 1)与N 对甲苯磺酰基 -二乙烯三胺 ( 2 )在醇钠条件下制备 5的方法简便可行 ,易于纯化 ,收率较高
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| 关 键 词： | 缩合 环合 大环多胺 |
| 修稿时间： | 2002-12-08 |
A Practical Synthesis of Hydroxyl-Substituted Macrocyclic Hexaamines |
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| LIANG,Feng WU,Cheng Tai. A Practical Synthesis of Hydroxyl-Substituted Macrocyclic Hexaamines[J]. Chinese Journal of Organic Chemistry, 2004, 24(4): 423-425 |
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| Authors: | LIANG Feng WU Cheng Tai |
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| Abstract: | Three methods were employed to synthesize title compound 3,13 dihydroxyl 1,5,8,11,15,18 hexaaza cyclicamines (5). A detailed study of the preparation of condensation product 5 was made by means of the reaction of 1,3 dichloro 2 propanol (1) with N tosyl diethylenetriamine (2). The reported synthesis procedure is simple and convenient, and the yield was raised. The product was easily isolated and purified. |
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| Keywords: | condensation cyclization macrocyclic polyamines |
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