溴化苄基取代吡啶类季铵盐的制备和抗菌性能

抗菌材料和抗菌制品的研究与应用一直是世界各国研究的重要课题~([1-3]),其中有机抗菌剂占据主要地位.季铵盐是研究比较多的一类有机抗菌剂,它们表现出良好的物理性质,如胶束浓度低,黏弹性好和溶解性强~([4]),同时此类抗菌剂具有强效的抗菌作用~([5]),引起了人们的极大兴趣.季铵盐广泛应用于医药、卫生、食品、饲料工业、农业、纺织、塑料、橡胶、造纸、水处理、油田开采、涂料、日常生活等多种领域~([6-10]).

Synthesis and antibacterial properties of benzyl substituted pyridine bromide quaternary ammonium salts

Four benzyl substituted pyridine bromide quaternary ammonium salts, 1-benzyl-2'-methylpyridinium bromide ([Bz-2-CH_3Py] Br), 1-benzyl-4'-methylpyridinium bromide ([Bz-4-CH_3Py] Br), 1-benzyl-4'-aminopyridinium bromide ([Bz-4-NH_2Py] Br) and 1-benzyl-4'-dimethylaminopyridinium bromide ([BzDMAP] Br), were synthesized by the reaction of benzyl bromide and 2-methylpyridine,4-methylpyridine,4-aminopyridine or 4-dimethylaminopyridine. Their components and structures were characterized by elemental analyses, infrared spectra, electronic spray mass spectra and conductivity. The experimental results of antibacterial activities indicated that the four salts exhibited good antibacterial properties for colibacillus, bacillus subtilus, aurococcus and bacillus thuringiensis.