3+2] cycloaddition reactions in the solid-phase synthesis of 1,2,3-triazoles |
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| Authors: | Gao Yongnian Lam Yulin |
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| Affiliation: | Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543. |
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| Abstract: | [Structure: see text] An efficient and regioselective procedure for the synthesis of 1,2,3-triazoles via a [3+2] cycloaddition of polymer-bound vinyl sulfone and sodium azide is described. Microwave irradiation provided significant rate enhancement in all steps of the three-step protocol. A representative set of 23 compounds was prepared. |
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