MUTAGENICITY OF MONOADDUCTS AND CROSS-LINKS INDUCED IN ASPERGILLUS NIDULANS BY 8-METHOXYPSORALEN PLUS 365 NM RADIATION |
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| Authors: | Barry R Scott Mary Ann Maley |
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| Institution: | The University of Texas System Cancer Center, Science Park-Research Division, P.O. Box 389, Smithville, TX 78957, USA |
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| Abstract: | Abstract— 8-Methoxypsoralen plus 365 nm radiation induces mutation at the methionine supressor loci of Aspergillus inhibitor-deficient conidia at low doses of near-UV radiation with one-hit kinetics and at higher near-UV radiation doses with two-hit kinetics. These results and others suggest that both monoadducts and cross-links, formed by 8-methoxypsoralen and DNA upon exposure to UV radiation, are capable of inducing mutation. Evidence is also presented that induced furocoumarin cross-links are responsible for the inactivation of the Aspergillus conidium. |
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