New method in synthesizing an optical active intermediate for (R,R)-formoterol |
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作者姓名: | Wei Fan Lei Chen Li Hai Yong Wu |
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作者单位: | Key Laboratory of Drug Targeting Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China |
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基金项目: | This work was supported by the National Natural Science Foundation of China (No. 29972013). |
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摘 要: | (R)-1-(4-Methoxyphenyl)propan-2-amine 2a, an optical active intermediate for (R,R)-formoterol, was synthesized from Dalanine in 65% overall yield by using a simple route, which contained protecting amino group, cyclization, coupling with Grignard reagent, reduction and deprotection.
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关 键 词: | 4-甲氧苯基 营养药 中间体 合成方法 |
收稿时间: | 2007-10-23 |
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