At clinically relevant concentrations the anaesthetic/amnesic thiopental but not the anticonvulsant phenobarbital interferes with hippocampal sharp wave-ripple complexes |
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| Authors: | Costas Papatheodoropoulos Evangelos Sotiriou Dimitrios Kotzadimitriou Panagiota Drimala |
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| Institution: | (1) Department of Physiology, Medical School, University of Patras, Rion, Greece;(2) Division of Basic Neurosciences, Foundation for Biomedical Research of the Academy of Athens (IIBEAA), Athens, Greece;(3) Central and North West London Mental Health NHS Trust, Substance Misuse Service, 5-7 Wolverton Gardens, W6 7DY London, UK |
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| Abstract: | Background Many sedative agents, including anesthetics, produce explicit memory impairment by largely unknown mechanisms. Sharp-wave
ripple (SPW-R) complexes are network activity thought to represent the neuronal substrate for information transfer from the
hippocampal to neocortical circuits, contributing to the explicit memory consolidation. In this study we examined and compared
the actions of two barbiturates with distinct amnesic actions, the general anesthetic thiopental and the anticonvulsant phenobarbital,
on in vitro SPW-R activity. |
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