Absorption,fluorescence and resonance Raman spectra of adriamycin and its complex with DNA |
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| Affiliation: | 1. Departamento de Química, Universidad del Cauca, Carrera 2 Calle 15N Esquina, Campus Tulcán, Popayán, Colombia;2. Departamento de Educación y Ciencias Básicas, Instituto Tecnológico Metropolitano, Calle 73 No. 76A–354, Medellín, Colombia;3. Departamento de Química, Universidad del Valle, A.A. 25360, Cali, Colombia;4. Department of Chemistry, University of Wisconsin, Madison, WI 53706, United States;5. Instituto de Química, Universidad de Antioquia, Calle 70 No. 52–21, Medellín, Colombia;1. Institut für Physikalische Chemie, Universität Mainz, D-55099 Mainz, Germany;2. I. Physikalisches Institut, Universität zu Köln, Zülpicher Str. 77, D-50937 Köln, Germany |
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| Abstract: | Absorption, fluorescence and resonance Raman spectra of adriamycin and of its complex with DNA have been measured. These results together with the analysis of the excitation profiles of the solid drug were used to interpret the complex pattern of the absorption spectra as due to the vibronic structure of a single electronic state. In addition a surplus band, depending on the concentration, was attributed to self-association.Further support was given for the intercalation nature of the drug-DNA complex. In particular it was found that the monomer form of adriamycin interacts with the nucleic acid and that interaction involves the whole chromophore framework. |
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