Delivery of active DACH-Pt anticancer species by biodegradable amphiphilic polymers using thiol-ene radical addition |
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| Authors: | Xiao Haihua Zhou Dongfang Liu Shi Qi Ruogu Zheng Yonghui Huang Yubin Jing Xiabin |
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| Institution: | State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China. |
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| Abstract: | A biodegradable and amphiphilic copolymer, mPEG-b-P(LA-co-MAC/TMA) that contains pendant 1,2-bidentate carboxyl groups is synthesized by thiol-ene radical addition and is further used to chelate with the active anticancer species (DACH-Pt) of oxaliplatin to form an mPEG-b-P(LA-co-MAC/TMA-Pt-DACH) complex. The polymer platinum complex can self-assemble into micelles. In vitro studies show that the DACH-Pt micelles display enhanced or comparable cytotoxicity against SKOV-3 and MCF-7 cancer cells, while they show reduced toxicity to HeLa cells compared with oxaliplatin. |
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| Keywords: | cancer therapy drug delivery systems micelles oxaliplatin thiol‐ene addition |
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