Isolation of sesquiterpenoids from sponge Dysidea avara and chemical modification of avarol as potential antitumor agents |
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Authors: | Shen Ya-Ching Lu Ching-Hau Chakraborty Rupak Kuo Yau-Haur |
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Affiliation: | Institute of Marine Resources, National Sun Yat-sen University, 70 Lien Hai Rd., Kaohsiung, Taiwan, Republic of China. |
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Abstract: | The marine sponge Dysidea avara contained avarol (1) and avarone (2). Avarol on acylation yielded 2',5'-O-dibenzoylavarol (3); 2,5'-O-(4-chlorobenzoyl)avarol (4); 2,5'-O-dicinnamoylavarol (5); 2,5'-O-(4-bromobenzoyl)avarol(6); 2',5'-O-dioctanoylavarol (7); 2',5'-O-(4-fluorobenzoyl)avarol (8) and diacetylavarol (9). The structural elucidation of all the compounds 1-9 have been done by spectral analysis. The cytotoxicity of these compounds were also determined and evaluated. Compounds 6 and 9 showed selective cytotoxicity against Hepa (human hepatoma) and KB cell lines respectively. |
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