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A convenient synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl) butanoates from malic acid |
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| Authors: | Yong Zhang MNaseer AKhanb Ping Gonga Yong Sup Lee a School of Pharmaceutical Engineering Shenyang Pharmaceutical University Wenhua Road Shenhe District Shenyang PR China b Kyung Hee East-West Pharmaceutical Research Institute |
| Institution: | a School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang 110016, PR China;b Kyung Hee East-West Pharmaceutical Research Institute and Department of Pharmaceutical Sciences, College of Pharmacy, Kyunghee University, Seoul 130-701, Republic of Korea |
| Abstract: | A synthesis of methyl 2-hydroxy-4-oxo-4-(substituted phenyl)butanoates has been accomplished using Friedel-Crafts acylation of substituted benzenes with 2-acetoxybutanoyl chloride.The key feature of this strategy is that various 4-arylbutanoates can be obtained conveniently,which are important intermediates for the synthesis of biologically active compounds including ACE inhibitors. |
| Keywords: | 2-Hydroxy-4-oxo-4-phenylbutanoates Malic acid Friedel-Crafts reaction |
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