N,N-bond-forming heterocyclization: synthesis of 3-alkoxy-2H-indazoles |
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| Authors: | Mills Aaron D Nazer Musa Z Haddadin Makhluf J Kurth Mark J |
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| Institution: | Department of Chemistry, University of California, One Shields Avenue, Davis, CA 95616, USA. |
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| Abstract: | A one-step heterocyclization of o-nitrobenzylamines to 3-alkoxy-2H-indazoles is reported. The electronic nature of the nitrophenyl group, the steric and electronic nature of the R1-functionalized benzylic amine, and the nature of the alcoholic solvent affect the efficiency of this heterocyclization reaction (approximately 40-90%). |
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