| 新型4,4-二甲基异噁唑-3-酮衍生物的合成及生物活性研究 |
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| 引用本文： | 杨桂秋,孙挺,于秀兰.新型4,4-二甲基异噁唑-3-酮衍生物的合成及生物活性研究[J].化学通报,2006,69(12):921-925. |
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| 作者姓名： | 杨桂秋 孙挺 于秀兰 |
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| 作者单位： | 东北大学理学院，东北大学理学院，沈阳化工学院制药工程系 沈阳110004，沈阳化工学院制药工程系，沈阳110142，沈阳110004，沈阳110142 |
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| 摘 要： | 以Baylis-Hillman加成物为起始原料,设计并合成了5个结构新颖的4,4-二甲基异唑-3-酮衍生物。所合成的化合物经IR、1HNMR和元素分析确证。生物活性测试结果表明,所合成的目标产物在2000gai/ha的剂量下均具有较好的除草活性。中间体1-(2,4-二氯苯基)-2-溴甲基丙烯酸乙酯具有杀虫活性,在600gai/ha的剂量下对朱砂叶螨防效为100%。
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| 关 键 词： | Baylis-Hillman加成物 N-取代-4 4-二甲基异噁唑-3-酮 合成 生物活性 |
| 收稿时间： | 2006-02-27 |
| 修稿时间： | 2006-02-272006-09-25 |
Synthesis and Biological Activity of Novel 4,4-Dimethylisoxazolidin-3-one Derivatives |
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| Yang Guiqiu,Sun Ting,Yu Xiulan.Synthesis and Biological Activity of Novel 4,4-Dimethylisoxazolidin-3-one Derivatives[J].Chemistry,2006,69(12):921-925. |
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| Authors: | Yang Guiqiu Sun Ting Yu Xiulan |
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| Institution: | 1.School of Sciences, Northeastern University, Shenyang 110004; 2.Department of Pharmaceutical Engineering, Shenyang Institute of Chemical Technology, Shenyang 110142 |
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| Abstract: | Five novel 4,4-dimethylisoxazolidin-3-one derivatives were designed and synthesized utilizing Baylis-Hillman adducts as starting materials. Their structures were confirmed by IR, ~1H NMR and elemental analysis. Evaluation of their biological activities indicated that the target compounds exhibited efficient herbicidal activity at 2000g ai/ha, while the intermediate ethyl 1-(2,4-dichlorophenyl)-2-bromomethyl-acrylate showed insecticidal activity with 100% control of tetranychus cinnabarinus at 600g ai/ha. |
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| Keywords: | Baylis-Hillman adduct N-Substituted-4 4-dimethylisoxazolidin-3-one Synthesis Biological activity |
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