Palladium-Catalyzed Regioselective Synthesis of 2-SF5-Indenols and Further Derivatizations |
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| Authors: | Lucas Popek Murat Cihan Dr. Nicolas Blanchard Dr. Vincent Bizet |
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| Affiliation: | Université de Haute-Alsace, Université de Strasbourg, CNRS, LIMA, UMR 7042, 68000 Mulhouse, France |
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| Abstract: | A palladium-catalyzed synthesis of 2-SF5-indenols has been developed by reacting commercially available boronic acid derivatives and readily accessible SF5-alkynes. The present methodology is fully regioselective thanks to the intrinsic polarization of SF5-alkynes. A selection of downstream functionalizations has been performed to highlight the versatility of 2-SF5-indenols and indenones as platforms for the design of more complex SF5-containing molecules. |
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| Keywords: | Diastereoselectivity Indanone Indenol Indenone Pentafluorosulfanyl Regioselectivity SF5 |
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