Perspective: The complex relationship between charge,mobility, and gas-phase protein structure |
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| Authors: | Ian K. Webb |
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| Affiliation: | Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, Indianapolis, Indiana, USA |
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| Abstract: | Ion mobility spectrometry coupled to mass spectrometry (IMS/MS) is a widely used tool for biomolecular separations and structural elucidation. The application of IMS/MS has resulted in exciting developments in structural proteomics and genomics. This perspective gives a brief background of the field, addresses some of the important issues in making structural measurements, and introduces complementary techniques. |
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| Keywords: | ion chemistry ion conformation ion mobility native mass spectrometry structural proteomics |
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