几种姜黄素类1,4-戊二烯-3-酮衍生物的合成及结构表征

以芳香醛和酮为原料,合成了3类姜黄素类1,5-二芳基-1,4-戊二烯-3-酮衍生物:1,5-二噻吩基-1,4-戊二烯-3-酮(Ⅰ)、1,5-二苯基-1,4-戊二烯-3-酮类(Ⅱ)和1,5-二呋喃基-1,4-戊二烯-3-酮(Ⅲ);利用元素分析、红外光谱、核磁共振谱(1 H NMR及13 C NMR)分析了产物的组成和结构,初步探讨了其反应条件和反应机理.结果表明,以无水乙醇为溶剂、8%的NaOH溶液为催化剂,反应温度为30⁵0℃时,反应产率较高.

Synthesis and structural characterization of several curcumintype 1,4-pentadiene-3-one derivatives

Three kinds of curcumin-type 1,5-diaryl-1,4-pentadien-3-one derivatives, 1,5-bis （3′-methyl-2′-thienyl）-1, 4-pentadiene-3-ketone （ Ⅰ ）, 1, 5-diphenyl-1, 4-pentadiene-3-ketone （ Ⅱ ） and 1,5-furyl-Ⅰ,4-pentadiene-3-ketone （ Ⅲ ） were designed and synthesized with aromatic aldehyde and ketone as the raw materials. The composition and structure of as-synthesized products were characterized by elemental analysis, infrared spectrometry and nuclear magnetic resonance （1H NMR, 13C NMR） spectroscopy. Moreover, the reaction conditions and reaction mechanisms were preliminarily discussed. Results show that target products can be obtained in relatively high yield at 30-50 ℃ in the presence of ethanol as the solvent and 8% NaOH solution as the catalyst.