Enantioselective alkynylation of aromatic and heteroaromatic aldehydes catalyzed by resin-supported oxazolidine-titanium complexes |
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| Authors: | Jincheng Mao Zhijian Bao Jun Guo Shunjun Ji |
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| Institution: | Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215123, PR China |
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| Abstract: | Highly enantioselective asymmetric addition of terminal alkynes to various aromatic and heteroaromatic aldehydes catalyzed by the readily available, low-cost, and reusable resin-supported oxazolidine 4 together with Ti(OiPr)4 provides the chiral propargylic alcohols with good to excellent yields (up to 98%) and enantioselectivities (up to 95%). The immobilized catalyst can be recovered and used for five cycles. |
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