10-23 DNA enzymes for targeting MDR1 mRNA |
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| Authors: | M A Kuznetsova M N Repkova A A Fokina A G Venyaminova V V Vlassov |
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| Institution: | (1) Novosibirsk Institute of Bioorganic Chemistry, 8 prosp. Akad. Lavrent"eva, 630090 Novosibirsk, Russian Federation;(2) Novosibirsk State University, 2 ul. Pirogova, 630090 Novosibirsk, Russian Federation |
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| Abstract: | The properties of the 31-mer 10-23 DNA enzyme and its analog with the terminal 3"-3" internucleotide linkage, which are complementary to an mRNA region of the multi-drug resistance gene MDR1, were investigated. DNA enzymes can selectively cleave RNA with high efficiency in a catalytic mode as exemplified by a synthetic 18-mer fragment of MDR1 mRNA. |
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| Keywords: | 10-23 DNA enzyme RNA cleavage multi-drug resistance gene MDR1 |
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