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| Synthesis and Crystal Structure of （E）-Ethyl 3-Keto-18β-glycyrrhetinate 3-Oxime | |
| 作者姓名： | CAI Chao YU Zhao-Yun REN Hong WANG Xi-Zhao WANG Jian-Wu |
| 作者单位： | School of Chemistry and Chemical Engineering Shandong University，Hebei University Health Science Center Hebei University，School of Chemistry and Chemical Engineering Shandong University，School of Chemistry and Chemical Engineering Shandong University，School of Chemistry and Chemical Engineering Shandong University，Jinan 250100 China，Baoding 071000 China，Jinan 250100 China，Jinan 250100 China，Jinan 250100 China |
| 基金项目： | The project was supported by the Natural Science Foundation of Shandong Province (No. Z2004C06)，National Basic Research Priority Program (2003CCA027) |
| 摘 要： | A novel derivative of glycyrrhetinic acid, (E)-ethyl 3-keto-18β-glycyrrhetinate 3- oxime C32H49NO4 (Mr = 511.72), was synthesized and structurally characterized by IR, 1H NMR and single-crystal X-ray diffraction. It belongs to monoclinic, space group P21, with a = 12.4897(12), b = 7.3190(7), c = 15.9944(14) , β = 94.833(2)o, V = 1456.9(2) 3, Z = 2, Dc = 1.167 g/cm3, μ = 0.075 mm-1, F(000) = 560, the final R = 0.0449 and wR = 0.1122. A total of 7486 reflections were collected, of which 2785 were independent (Rint = 0.0199) and 2605 were observed with I > 2σ(I). There exists an intermolecular hydrogen bond which helps to stabilize the crystal structure. |
| 关 键 词： | synthesis crystal structure ethyl 18β-glycyrrhetinate oxime |
| 收稿时间： | 2006-12-18 |
| 修稿时间： | 2007-01-23 |
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