Facile Synthesis of Single‐Phase Mesoporous Gd2O3:Eu Nanorods and Their Application for Drug Delivery and Multimodal Imaging |
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Authors: | Chaohui Zhou Hui Wu Chusen Huang Mingliang Wang Nengqin Jia |
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Institution: | 1. The Education Ministry Key Laboratory of Resource Chemistry and Shanghai, Key Laboratory of Rare Earth Functional Materials, Department of Chemistry, Shanghai Normal University, , Shanghai, 200234 China;2. Department of Radiology, Zhongshan Hospital, Fudan University, , Shanghai, 200032 China |
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Abstract: | In this work, a new and facile strategy is developed to synthesize a single‐phase Eu3+‐doped mesoporous gadolinium oxide nanorods (MS‐Gd2O3:Eu@PEG) by incorporating a facile wet‐chemical route, which includes an induced silica layer being coated onto the nanorods, and evolution of pores and formation of channels, as well as a surface‐modified process for multimodal imaging and anti‐cancer drug delivery. The properties of these as‐prepared Gd2O3:Eu nanorods are characterized by transmission electron microscopy (TEM), X‐ray diffraction (XRD), N2 adsorption/desorption, and photoluminescence (PL). The in vitro cytotoxicity test, drug loading, and drug release experiments reveal that the MS‐Gd2O3:Eu@PEG nanorods have good biocompatibility, efficient loading capacity, and pH‐sensitive releasing behavior, suggesting the nanorods could be an ideal candidate as drug delivery vehicles for cancer therapy. Furthermore, the MS‐Gd2O3:Eu@PEG nanorods show clearly dose‐dependent contrast enhancement in T1‐weighted magnetic resonance images and can potentially be used as a T1‐positive contrast agent. These results indicate our prepared multifunctional mesoporous gadolinium oxide nanorods can serve as a promising platform for simultaneous anti‐cancer drug delivery and multimodal imaging. |
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Keywords: | mesoporous nanorods facile synthesis Gd2O3:Eu drug delivery imaging |
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