Gelation characteristics and applications of poly(ethylene glycol) end capped with hydrophobic biodegradable dipeptides |
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Authors: | G. Rajesh Krishnan Yuan Yuan Ayesha Arzumand Debanjan Sarkar |
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Affiliation: | 1. Department of Biomedical Engineering, University at Buffalo, State University of New York, , Buffalo, New York, 14260;2. Department of Chemical and Biological Engineering, University at Buffalo, State University of New York, , Buffalo, New York, 14260 |
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Abstract: | Poly(ethylene glycol) (PEG) end capped with biodegradable hydrophobic dipeptides shows versatile gelation behavior in a wide range of aqueous and organic solvents. This gelation characteristic is attributed to the aggregation of polymer chains induced by dipeptide end groups. Both PEG molecular weight and molecular structure of end groups control this aggregation by striking a balance between two opposing molecular interactions: solubility of the PEG segment which tends to dissolve the polymer while hydrophobic and intermolecular noncovalent interactions between the end groups induce aggregation. Morphologically, this aggregated structure forms interpenetrating nano sheets with characteristic microstructural features. These gels are biodegradable and possess physicomechanical characteristics suitable for biomedical applications. Furthermore, proteins and hydrophobic model drugs can be encapsulated within the gels from aqueous and organic solvents, respectively, and can be released in a controlled fashion which indicates the applicability of the gels as drug delivery vehicles. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2014 , 52, 1917–1928 |
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Keywords: | drug delivery systems hydrogel nanolayers organogel poly(ethylene glycol) tyrosine |
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