Molecular properties of hybrid macromolecular antioxidants: Dextran hydrophobically modified by sterically hindered phenols |
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Authors: | S K Filippov B Porsch O Yu Sergeeva A S Olifirenko S B Lesnichin N S Domnina E A Komarova A V Lezov V M Garamus Z Walterova P Štepanek |
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Institution: | Institute of Macromolecular Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic. filippov@imc.cas.cz |
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Abstract: | The conformation properties of clinically relevant hybrid macromolecular antioxidants (dextran hydrophobically modified by sterically hindered phenols) in aqueous solution were characterized by a combination of dynamic light scattering (DLS), size exclusion chromatography (SEC), and small-angle neutron scattering (SANS). We were able to split and analyze separately two different types of polydispersity -polydispersity over molecular weights and the one over substitution degree. The properties of the hybrid macromolecules are determined by the number of hydrophobic antioxidants in a single molecule. An insertion of hydrophobic groups into a hydrophilic chain changes the conformation of a single conjugate macromolecule. We have established that with the increasing of a number of hydrophobic antioxidant groups, a conformational transition occurs where a single conjugate undergoes a transition from a Gaussian coil conformation to a more compact structure. |
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