Synthesis of chiral sulfoximines derived from 3-aminoquinazolinones and their catalysis of enantioselective diethylzinc addition to aldehydes |
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| Authors: | Karabuga Semistan Cakici Murat Kazaz Cavit Sahin Ertan Kilic Hamdullah Ulukanli Sabri |
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| Affiliation: | Department of Chemistry, Faculty of Science and Letters, Kahramanmaras Sutcu Imam University, 46100, Kahramanmaras, Turkey. |
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| Abstract: | A series of sulfoxides were sulfoximinated using oxidative addition of 3-aminoquinazolinones by lead tetraacetate in the presence of hexamethyldisilazane. They were applied for the first time in catalytic enantioselective addition to aromatic aldehydes with a product enantiopurity (ee) of 92% in the case of 2-methoxybenzaldehyde. |
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