Biological Properties of New Chiral 2-Methyl-5,6,7,8-tetrahydroquinolin-8-amine-based Compounds |
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| Authors: | Giorgio Facchetti Michael S Christodoulou Lina Barragn Mendoza Federico Cusinato Lisa Dalla Via Isabella Rimoldi |
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| Institution: | 1.DISFARM, Sezione di Chimica Generale e Organica “A. Marchesini”, Università degli Studi di Milano via Venezian, 21, 20133 Milano, Italy; (M.S.C.); (I.R.);2.Dipartimento di Scienze del Farmaco, Università degli Studi di Padova, via F. Marzolo, 5, 35131 Padova, Italy; (L.B.M.); (F.C.);3.Facultad de Ciencias Químicas, Universidad de Colima, Carr. Colima-Coquimatlán km 9, Coquimatlán 28400, Colima, Mexico |
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| Abstract: | The synthesis of a small library of 8-substituted 2-methyl-5,6,7,8-tetrahydroquinoline derivatives is presented. All the compounds were tested for their antiproliferative activity in non-cancer human dermal microvascular endothelial cells (HMEC-1) and cancer cells: human T-lymphocyte cells (CEM), human cervix carcinoma cells (HeLa), human dermal microvascular endothelial cells (HMEC-1), colorectal adenocarcinoma (HT-29), ovarian carcinoma (A2780), and biphasic mesothelioma (MSTO-211H). Compounds 3a, 5a, and 2b, showing significant IC50 values against the whole panel of the selected cells, were further synthesized and tested as pure enantiomers in order to shed light on how their stereochemistry might impact on the related biological effect. The most active compound (R)-5a was able to affect cell cycle phases and to induce mitochondrial membrane depolarization and cellular ROS production in A2780 cells. |
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| Keywords: | Schiff bases ROS production mitochondrial damage tetrahydroquinolines antiproliferative activity |
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