二硫化碳对机体铜、锌水平的影响

为观察二硫化碳（CS2）对机体铜，锌水平的影响，对某化纤厂35名接触CS2工人和41名非接触工人的血铜，锌值进行调查，比较，并进行了动物染毒实验。SD大鼠吸入CS2浓度分别为5和50mg/m^3，每日5h，每周6d，连续6个月，于染毒2，4，6个月时测定血浆铜，锌值及染毒6个月时肝脏铜，锌含量。结果显示，CS2接触组工人血铜，锌水平较对照组显著降低（P＜0．05）。在CS2染毒6个月时，50mg/m^3 CS2染毒组血浆及肝脏铜水平均较对照组及5mg/m^3 CS2染毒组显著降低（P＜0．05）。可见接触CS2能干扰机体铜，锌代谢，导致体内铜，锌含量减少。

Effects on the Copper and Zinc in Organisms Chronically Exposed to Carbon Disulfide

To observe the effects of carbon disulfide(CS 2)on the copper and zine in exposed organisms,the concentrations of serum copper and zinc in 35 workers exposed to CS 2 and 41 no-exposure workers were determined and analysed.Sprague Dawley rats were inhaled respectively 5 mg/m 3 and 50 mg/m 3 CS 2 vapours 5 h in a day,6 day in a week for six months.The concentrations of copper and zinc in plasma and liver were determined after 2,4 and 6 months of CS 2 exposure. The result showed that the concentrations of serum copper and zinc in workers exposed to CS 2 were significantly decreased ( P <0 05),and the levels of copper in plasma and liver in the rats that inhaled 50 mg/m 3 CS 2 vapour after six months exposure were also significantly decreased( P <0 05).It concluded exposure to CS 2 can interfere with copper and zinc metabolism,and decrease the content of copper and zinc in organisms.