A trinuclear heterobimetallic Ru(II)/Pt(II) complex as a chemodosimeter selective for sulfhydryl-containing amino acids and peptides |
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Authors: | Chow Cheuk-Fai Chiu Brenda K W Lam Michael H W Wong Wai-Yeung |
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Institution: | Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Hong Kong SAR, China. |
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Abstract: | A trinuclear heterobimetallic Ru(II)/Pt(II) complex, cis-{Ru(phen)2CN-Pt(DMSO)Cl2]2} (phen = 1,10-phenanthroline), is able to function as a "switch-on" luminescent chemodosimeter for sulfhydryl-containing amino acids and peptides via specific binding of the amino acids/peptides with the Pt(II) centers and the subsequent cleavage of the Ru(II)-Pt(II) cyano-bridge. |
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