Microwave-accelerated methodology for the direct reductive amination of aldehydes |
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Authors: | Kangasmetsä Jussi J Johnson Tony |
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Institution: | Medivir UK Ltd., Chesterford Research Park, Little Chesterford, Essex CB10 1XL, UK. jussi.kangasmetsa@medivir.com |
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Abstract: | chemical reaction: see text]. An improved procedure for the direct reductive amination of aldehydes was developed which uses dibutyltin dichloride as catalyst in the presence of phenylsilane as reductant. Rapid reaction is promoted by the use of microwave conditions with anilines, secondary and primary amines being suitable reactants. |
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