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Fluctuation theorem for the mutation process in in vitro evolution |
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| Authors: | Liu Qi Tang Chao Ouyang Qi |
| Affiliation: | Center for Theoretical Biology, Peking University, Beijing {rm100871, China;California Institute for Quantitative Biomedical Research,Departments of Biopharmaceutical Sciences and Biochemistry andBiophysics, University of California, San Francisco, CA 94143,USA; Department of Physics, Peking University, Beijing 100871,China;Center for Theoretical Biology, Peking University, Beijing {rm100871, China |
| Abstract: | A proposition based on the fluctuation theorem inthermodynamics is formulated to quantitatively describe molecularevolution processes in biology. Although we cannot give full proofof its generality, we demonstrate via computer simulation itsapplicability in an example of DNA in vitro evolution.According to this theorem, the evolution process is a series ofexponentially rare fluctuations fixed by the force of naturalselection. |
| Keywords: | fluctuation theorem molecular evolution naturalselection |
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