|
|||||
|
|
| 抗凝血生物材料* | |
| 引用本文： | 何淑漫,周健.抗凝血生物材料*[J].化学进展,2010,22(4):760-772. |
| 作者姓名： | 何淑漫 周健 |
| 作者单位： | （华南理工大学 化学与化工学院 广东省绿色化学产品技术重点实验室 广州 510640） |
| 基金项目： | 教育部新世纪优秀人才支持计划 |
| 摘 要： | 本文对抗凝血材料的研究进展进行了综述，着重介绍了血栓形成及凝血机理、提高生物材料表面抗凝血性能的改性材料和改性技术、抗凝血材料的表征等几方面的内容；分析了当前抗凝血材料研究中存在的问题，并对今后从分子水平上设计新型抗凝血材料进行了展望。 |
| 关 键 词： | 抗凝血 生物材料 生物相容性 蛋白质吸附 分子模拟 |
| 收稿时间： | 2009-05-27 |
| 修稿时间： | 2009-07-02 |
Anticoagulant Biomaterials |
|
| He ShuMan,Zhou Jian.Anticoagulant Biomaterials[J].Progress in Chemistry,2010,22(4):760-772. | |
| Authors: | He ShuMan Zhou Jian |
| Institution: | (School of Chemistry and Chemical Engineering, Guangdong Provincial Key Lab for Green Chemical Product Technology, South China University of Technology, Guangzhou 510640, China) |
| Abstract: | In this paper, the research progress on anticoagulant materials is reviewed. The mechanism of blood clotting and thrombus formation, techniques to improve anticoagulant behavior of biomaterials, characterization methods for anticoagulant biomaterials are discussed. In addition, problems in this field are analyzed and a perspective regarding the molecular design of novel anticoagulant biomaterials is made.
Contents 1 Introduction 2 The formation mechanism and pathways of coagulation 3 The preparation of modified anticoagulant materials 3.1 Physical and chemical modification of material surfaces 3.2 Biological modification of material surfaces to form pseudointima 3.3 Addition of bioactive materials 3.4 Comparison of anticoagulant materials 4 The characterization of anticoagulant materials 4.1 Infrared spectroscopy 4.2 Atomic force microscopy 4.3 X-ray photoelectron spectroscopy 4.4 Scanning electron microscopy 4.5 Surface plasmon resonance 4.6 Quartz crystal microbalance 4.7 Evaluation of characterization techniques 5 Conclusion and prospects |
| Keywords: | anticoagulation biomaterials biocompatibility protein adsorption molecular simulation |
| 本文献已被 CNKI 等数据库收录！ | |
| 点击此处可从《化学进展》浏览原始摘要信息 | |
| 点击此处可从《化学进展》下载免费的PDF全文 | |