Spectrophotometric simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form |
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Authors: | Sabnis Shweta S Dhavale Nilesh D Jadhav Vijay Y Gandhi Santosh V |
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Institution: | Department of Pharmaceutical Analysis, A.I.S.S.M.S. College of Pharmacy, Kennedy Road, Near R.T.O., Pune 411 001, Maharashtra, India. |
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Abstract: | A new simple, economical, rapid, precise and accurate method for simultaneous determination of rabeprazole sodium and itopride hydrochloride in capsule dosage form has been developed. The method is based on ratio spectra derivative spectrophotometry. The amplitudes in the first derivative of the corresponding ratio spectra at 231nm (minima) and 260nm were selected to determine rabeprazole sodium and itopride hydrochloride, respectively. The method was validated with respect to linearity, precision and accuracy. |
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