Non-invasive Near Infrared Fluorescence Imaging of CdHgTe Quantum Dots in Mouse Model |
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Authors: | Haiyan Chen Yunqing Wang Jing Xu Jinzi Ji Jian Zhang Yuzhu Hu Yueqing Gu |
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Institution: | Department of Biomedical Engineering, School of Life Science and Technology, China Pharmaceutical University, 24 Shennong Road, Nanjing, 210009, People's Republic of China. |
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Abstract: | Near infrared CdHgTe quantum dots (QDs) acted as biomarker for in vivo imaging were synthesized in aqueous solution. The size
and the fluorescence wavelength of the synthesized quantum dots can be arbitrary manipulated by using different refluxing
time. In particular, the fluorescence wavelength was extended to near infrared range (700∼900 nm), which make the in vivo
imaging possible. Meanwhile, the characteristics, such as morphology, size, spectra, stability and toxicity were investigated.
The dynamic bio-distribution, clearance from blood, liver and intestine in living animal were in vivo monitored by a NIR imaging
system. The circulation of CdHgTe QDs in living mice was addressed semi-quantitatively according to the changes of fluorescence
intensity. The high stability as well as high fluorescence intensity makes QDs particular interested candidates for in vivo
imaging studies. |
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Keywords: | Near infrared Quantum dots Stability In vivo Fluorescence imaging |
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