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Synthese von Dibenzo[a,g]chinolizinen — Ein neuer Zugang zu Protoberberinen |
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| Authors: | Eberhard Reimann Helmut Benend |
| Affiliation: | (1) Institut für Pharmazie und Lebensmittelchemie der Universität München, D-W-8000 München 2, Bundesrepublik Deutschland |
| Abstract: | Summary A novel synthesis to prepare dibenzo-8-quinolizinones8 is reported using the intramolecular cyclisation of the benzylated Reissert compounds6 for the key step. Methylation of8 by methyllithium gives partial deoxygenated coralynes10 which in turn can be reduced by NaBH4 yielding the 8-methyltetrahydro-protoberberines11. The structures are assigned by NMR-spectroscopy. |
| Keywords: | Reissert compounds Intramolecular cyclisation Dibenzo[a,g]-8-quinolizinones Deoxygenated coralynes 8-Methyltetrahydro-protoberberines |
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