Inotilone and related phenylpropanoid polyketides from Inonotus sp. and their identification as potent COX and XO inhibitors |
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| Authors: | Wangun Hilaire V Kemami Härtl Albert Tam Kiet Trinh Hertweck Christian |
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| Institution: | Dept. Biomolecular Chemistry, Leibniz-Institute for Natural Products Research and Infection Biology, Jena, Germany. |
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| Abstract: | By bioassay-guided isolation, phenylpropanoid-derived polyketides, including an unusual 5-methyl-3(2H)-furanone derivative (inotilone) with potent cyclooxygenase (COX) and xanthone oxidase (XO) inhibitory activities were obtained from the fruiting body of the mushroom Inonotus sp. |
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