Capillary electrophoresis with electrochemiluminescence detection: fundamental theory,apparatus, and applications |
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Authors: | Longhua Guo FengFu Fu Guonan Chen |
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Institution: | (1) Ministry of Education Key Laboratory of Analysis and Detection, Fujian Provincial Key Laboratory of Analysis and Detection, Department of Chemistry, Technology for Food Safety, Fuzhou University, Fuzhou, 350002, China; |
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Abstract: | This review presents a comprehensive survey of recent progress on electrochemiluminescence (ECL) detection coupled with capillary
electrophoresis (CE). The fundamental theories involved in CE-ECL, e.g., the mechanism involving both coreactant-based and
inhibitor-based ECL, as well as the possible analytes to be detected by CE-ECL are summarized. Different schemes for the construction
of CE-ECL apparatus, including methods for preparing the working electrode, approaches for addition of ECL reagents, ways
to fabricate electrical decouplers, and factors affecting ECL efficiency are reviewed. Discussion of the literature related
to the application of CE-ECL from January 2005 to September 2010 is sorted by the corresponding analyte matrixes, namely,
the standard solution, urine, serum and plasma, and other matrixes. Finally, possible trends for CE-ECL in the near future
are discussed. |
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Keywords: | |
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