4-hydroxy-2-quinolones. 191.* synthesis,tautomerism and biological activity of benzimidazol-2-ylamides of 1-r-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids |
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| Authors: | I. V. Ukrainets L. A. Grinevich A. A. Tkach O. V. Gorokhova V. N. Kravchenko G. Sim |
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| Affiliation: | (1) National Pharmaceutical University, Kharkiv, 61002, Ukraine;(2) Far East State Medical University, Khabarovsk, 68000, Russia |
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| Abstract: | A series of benzimidazol-2-ylamides of 4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxylic acids was prepared in a search for biologically active compounds. These compounds exist in the crystal exclusively in the amide form, while in solution amide↔imide tautomerism is observed. The results of a study of the antithyroid and antituberculosis activities of these compounds are given. |
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