| 钌配合物断裂DNA及其机理研究 |
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| 引用本文： | 赵晓珑,王科志.钌配合物断裂DNA及其机理研究[J].中国科学:化学,2014(4):471-483. |
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| 作者姓名： | 赵晓珑 王科志 |
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| 作者单位： | [1]能量转换与存储材料北京市重点实验室：北京师范大学化学学院,北京100875 [2]河北大学化学与环境科学学院,保定071002 |
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| 基金项目： | 国家自然科学基金(21171022,90922004);北京师范大学分析测试基金资助 |
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| 摘 要： | DNA是遗传信息的携带者和基因表达的物质基础,金属配合物与DNA的相互作用研究受到广泛关注,成为生物无机化学的重要研究内容之一.与其他类型金属配合物相比,钌配合物具有良好的热力学稳定性以及丰富的光化学、光物理和氧化还原特性,其作为DNA断裂试剂也引起人们的极大兴趣.以近年一些代表性的研究工作为例,本文对钌配合物在DNA断裂作用机制方面的研究进展进行了综述.
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| 关 键 词： | 钌配合物 DNA断裂 机理 |
DNA cleavage mechanisms of ruthenium complexes |
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| ZHAO XiaoLong,＇,WANG KeZhi.DNA cleavage mechanisms of ruthenium complexes[J].Scientia Sinica Chimica,2014(4):471-483. |
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| Authors: | ZHAO XiaoLong ＇ WANG KeZhi |
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| Institution: | 1. 1 Beijing Key Laboratory of Energy Conversion and Conversion Materials; College of Chemistry, Beijing Normal University, Beijing 100875, China 2 College of Chemistry and Environmental Science, Hebei University, Baoding 071002, China |
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| Abstract: | DNA is the carder of genetic information and the material basis of gene expression. The interaction between metal complexes and DNA has attracted tremendous attention and become one of the most active research fields of bioinorganic chemistry. Ruthenium complexes, which possess excellent chemical stability and superior photochemical, photophysical and redox properties in comparison to other metal complexes, have also received intense interest as DNA cleavage agents. In this review, the recent representative advances on ruthenium complex-based DNA cleavers as well as the mechanisms of the DNA cleavage are highlighted. |
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| Keywords: | ruthenium complexes DNA cleavage mechanism |
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