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| 肝素功能化生物材料的研究进展 | |
| 引用本文： | 李娟,吴英锋,杨新林.肝素功能化生物材料的研究进展[J].有机化学,2010,30(3):359-367. |
| 作者姓名： | 李娟 吴英锋 杨新林 |
| 作者单位： | 1. 北京理工大学生命科学与技术学院,北京,100081 2. 北京市首都医科大学宣武医院血管外科,北京,100053 |
| 基金项目： | 北京市科技计划项目基金 |
| 摘 要： | 从物理吸附涂层、共价键连接和微载体控释等方面综述了肝素功能化生物材料的最新研究进展.大量研究表明这些肝素材料具有抗凝血和/或生长因子释放的功能,但未来的研究重点是构建各种控制释放肝素亲和性生长因子的系统. |
| 关 键 词： | 肝素 生长因子 功能化 生物材料 |
| 收稿时间： | 2009-04-07 |
| 修稿时间： | 2009-07-14 |
Progress in Heparin-Functionalized Biomaterials |
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| Li Juan,Wu Yingfeng,Yang Xinlin.Progress in Heparin-Functionalized Biomaterials[J].Chinese Journal of Organic Chemistry,2010,30(3):359-367. | |
| Authors: | Li Juan Wu Yingfeng Yang Xinlin |
| Institution: | (School of Life Science and Technology, Beijing Institute of Technology, Beijing 100081) (Department of Vascular Surgery, Xuanwu Hospital, Capital Medical University, Beijing 100053) |
| Abstract: | Ths recent progress in heparin-functionalization of biomaterials is reviewed. Achievements in materials preparation based on physical adsorption coatings, covalent graft and biomimetic microcarriers are included. All these heparin-containing materials have antithrombogenicity and/or can control the release of growth factors, which have been extensively investigated. However, the research in the near future will focus on construction of various systems to control the release of heparin affinitive growth factors. |
| Keywords: | heparin growth factor functionalization biomaterial |
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