Ultrahigh reactivity and grave nanotoxicity of copper nanoparticles |
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Authors: | Huan Meng Zhen Chen Gengmei Xing Hui Yuan Chunying Chen Feng Zhao Chengcheng Zhang Yun Wang Yuliang Zhao |
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Institution: | (1) Laboratory for Bio-Environmental Health Sciences of Nanoscale Materials, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, 100049, P.R. China;(2) The Graduate University of Chinese Academy of Sciences, Beijing, 100049, P.R. China;(3) National Center for Nanoscience and Nanotechnology, China, Beijing, 100081, P.R. China |
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Abstract: | Recently, it was reported that the toxicity of copper particles increases with the decrease of the particle size on a mass
basis. To understand this phenomenon, inductively coupled plasma mass spectrometry (ICP-MS) techniques and in vitro chemical
studies were carried out to explore how they produce toxicity in vivo. The results suggest that when the sizes of particles
become small and down to a nanoscale, copper becomes extremely reactive in a simulative intracorporeal environment. The nanosized
copper particles consume the hydrogen ions in stomach more quickly than micron ones. These processes further convert the copper
nanoparticles into cupric ions whose toxicity is very high in vivo. |
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